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Conferences > PIBM > 2017 > T1B > T1B.2

Actin Cytoskeletal Remodeling in the Regulation of Glucose Homeostasis

Man Mohan Shrestha, Chun-Yan Lim, and Weiping Han

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Abstract

Glucose transporter 4 (GLUT4) is a key regulator of systemic glucose homeostasis. We recently showed that GLUT4 translocation is regulated by actin remodeling triggered by insulin signaling. Here we present that AMPK-mediated phosphorylation of an actin-capping protein is required for GLUT4 exocytosis and glucose uptake in muscle cells.

© 2017 Optical Society of America

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