Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Rapid and in situ optical detection of trace lithium in tissue

Not Accessible

Your library or personal account may give you access

Abstract

Lithium-based medications are used against many mental disorders, including Bipolar disorder and Alzheimer’s disease. However, lithium’s distribution in organs and cells is poorly characterized due to limitations in detection. This limits the ability to improve lithium-based treatments. To address this need, laser induced breakdown spectroscopy (LIBS) is developed for rapid and in situ detection of lithium in tissues. Pronounced lithium emissions are observed at 670.7 nm from the rat thyroid and salivary glands. The lithium emission intensity is positively correlated with tissue lithium concentration (R2=0.80). When subjects are administered lithium orally, thyroid lithium intensity increases (p<0.05) while iodine intensity decreases (p<0.001). The reduced intrathyroidal iodine following administration likely impairs hormone production. This reduced intrathyroidal iodine is also observed when iodine is supplemented on the regular diet, which agrees with the hypothesis of Wolff–Chaikoff.

© 2018 The Author(s)

PDF Article
More Like This
Elemental analysis of mammary glands with laser induced breakdown spectroscopy

Irfan Ahmed and Condon Lau
JTh3A.50 Clinical and Translational Biophotonics (Translational) 2018

Broadband (600-1100 nm) Diffuse Optical Characterization of Thyroid Tissue Constituents and Application to in vivo Thyroid Studies

Sanathana Konugolu Venkata Sekar, Andrea Farina, Alberto Dalla Mora, Paola Taroni, Claus Lindner, Mireia Mora, Marco Pagliazzi, Mattia Squarcia, Irene Halperin, Felicia A. Hanzu, Hamid Dehghani, Turgut Durduran, and Antonio Pifferi
CF2B.3 Clinical and Translational Biophotonics (Translational) 2018

Novel clinical technology for rapid detection of tissue fluorescence wavelength-time matrices

William Lloyd, Ching-Wei Chang, Robert Wilson, Gregory Gillispie, and Mary-Ann Mycek
JMA96 Biomedical Optics (BIOMED) 2010

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved