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2D individual particle grids patterned with surface acoustic waves

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Abstract

Acoustic forces have the demonstrated ability to pattern particles and cells at locations of minimum acoustic force potential – more often than not at the acoustic ‘nodes’. However, as a result of the relatively low frequencies used, the wavelength is typically substantially larger than that of the dimensions of the particles that are patterned, resulting in the collection of clumps of particles rather than individual ones. However, with the relatively recent advent of surface acoustic waves (SAW) for microfluidic applications, it is now possible to generate acoustic fields with wavelengths on the order of microns. Here, using high-frequency SAW, we demonstrate for the first time the patterning in a 2D grid of individual particles using acoustic wavelengths on the order of the particle diameters themselves. Potential applications include single-cell analysis, where each cell is viewed and analyzed in isolation.

© 2015 Optical Society of America

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