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Conferences > OMP > 2011 > OMB > OMB2

Preliminary Intravital Microscopic Analysis Reveals Macrophage Uptake of Circulating Nanotubes and Peptide-Dependent Delivery into Tumor

Bryan R. Smith, Harikrishna Rallapalli, Jennifer Prescher, Cristina Zavaleta, Jarrett Rosenberg, Scott Tabakman, Hongjie Dai, and Sanjiv S. Gambhir

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Abstract

Nanoparticle targeting efficiency to tumor is poor and not well-understood. We applied intravital microscopy in a dorsal window chamber model to interrogate vasculature-targeted carbon nanotubes. We found that nanotubes program circulating macrophages to enter tumor.

© 2011 Optical Society of America

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