Pharmacokinetic Tomography of Cutaneous Drug Delivery with Advanced Fluorescence Microscopy

Kin F Chan; Maiko Hermsmeier; Sinyoung Jeong; Sam Osseiran; Sam Osseiran; Alexander Fast; Xin Chen; Akira Yamamoto; Conor L. Evans

doi:10.1364/NTM.2019.NM2C.2

Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP)
OSA Technical Digest (Optica Publishing Group, 2019),
paper NM2C.2
•https://doi.org/10.1364/NTM.2019.NM2C.2

Pharmacokinetic Tomography of Cutaneous Drug Delivery with Advanced Fluorescence Microscopy

Kin F Chan, Maiko Hermsmeier, Sinyoung Jeong, Sam Osseiran, Alexander Fast, Xin Chen, Akira Yamamoto, and Conor L. Evans

Novel Techniques in Microscopy 2019

Tucson, Arizona United States
14–17 April 2019
ISBN: 978-1-943580-54-5

From the session
Nonlinear Microscopy: Clinical Applications (NM2C)

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K. F. Chan, M. Hermsmeier, S. Jeong, S. Osseiran, A. Fast, X. Chen, A. Yamamoto, and C. L. Evans, "Pharmacokinetic Tomography of Cutaneous Drug Delivery with Advanced Fluorescence Microscopy," in Biophotonics Congress: Optics in the Life Sciences Congress 2019 (BODA,BRAIN,NTM,OMA,OMP), OSA Technical Digest (Optica Publishing Group, 2019), paper NM2C.2.

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Abstract

Cutaneous pharmacokinetics of active ingredients were investigated with single-and two-photon excited fluorescence microscopy. Two-photon excited fluorescence lifetime imaging enabled single-daily dose drug visualization and distribution with higher sensitivity and specificity.

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