Abstract

This talk will address the developments in new optical bioimaging methods, best suited for detecting and characterizing abnormalities, with high resolution (spatial, temporal, spectral, etc.) and specificity, such as superresolution, heterodyned coherence tomography, parametrically amplified NIR, using elastic scattering, confocal, multiphoton, lifetime, spectral, multimode preclinical imaging and endoscopy for minimally invasive image-guided surgery. We addressed some of the main limitations that have prevented the penetration of advanced optical imaging technologies into the operating room, by concentrating on methods that do not require contrast agents, using spectral, lifetime, non-linear and coherence based approaches, applied to light reflected, scattered, transmitted and emitted, as fluorescence and luminescence. Our intrasurgical optical imaging is based on a multimode implementation (combining the methods listed above) and is endoscopically optimized – through custom scanning and detection devices – for improved minimally invasive surgery with earlier detection of abnormalities.

© 2010 Optical Society of America