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Tens nanometer scale cathodoluminescence bioimaging with rare-earth doped nanophosphors

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Abstract

Cathodoluminescence (CL) microscopy has a potential to visualize and distinguish specific kinds of biomole-cules at higher spatial resolution than fluorescence microscopy imaging. Up to now, we have investigated multi-color CL observation with different kinds of rare-earth doped nanophosphors (NPs) [1, 2]. The previous results showed that small nanophosphors emit weak CL even though a few tens nm size of particles is indispensable for practical application. Therefore, the improvement of size and CL emission intensity are highly desired. We report the synthesis of highly emissive rare-earth doped NPs smaller than 50 nm and its CL imaging properties.

© 2014 Japan Society of Applied Physics, Optical Society of America

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