Abstract

Comparative IOS imaging of wild-type (WT) and rod-degenerated mutant mouse retinas was conducted to demonstrate IOS modification correlated with retinal disease. A rapid line-scan confocal ophthalmoscope was constructed to achieve in vivo IOS imaging at cellular and millisecond resolution. Comparative IOS and electroretinography (ERG) recordings revealed a close correlation between the confocal-IOS and retinal ERG, particularly the ERG a-wave. IOS identification of localized retinal dysfunction was validated using laser-injured frog eyes.

© 2013 Optical Society of America