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Quantitative characterization of tissue using optical spectroscopy

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Abstract

To optimize the use of spectroscopic techniques as tools for disease diagnosis or for monitoring and guiding therapy, it is essential to understand the origins of the detected signals and to characterize in a quantitative manner the biochemical and morphological information that these techniques provide. This has been achieved for the case of three spectroscopic techniques: intrinsic fluorescence spectroscopy (IFS), diffuse reflectance spectroscopy (DRS) and light scattering spectroscopy (LSS). Information from a combination of these techniques can be combined to provide a more complete picture of the tissue biochemistry and morphology and improved diagnostic capabilities.

© 2003 Optical Society of America

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