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Coherent Raman scattering (CRS) [1] is a nonlinear microscopy technique, which can enhance the Raman intensity by orders of magnitude compared to conventional spontaneous Raman measurements, ultimately reaching video-rate imaging speeds [1]. However, it comes at the cost of an increased experimental complexity. In particular, it requires synchronized ultra-fast lasers, where two ps pulses (pump and Stokes) are used to set up and detect a vibrational coherence within the sample [1,2]. This, together with the high cost and large footprint, still prevents CRS instrumentation from being translated to clinical environments.
© 2017 IEEE
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