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Conferences > ECBO > 2019 > CPII > 11075_11

Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert, Lewis Woolfson, Isla RM Barnard, Andrew Morton, Becky Casement, Gavin B Robertson, Gareth B Miles, Samantha J Pitt, Carl S Tucker, and Malte C Gather

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Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

© 2019 SPIE/OSA

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