Quantitative Optical Diagnostics in Pathology Recognition and Monitoring of Tissue Reaction to PDT

Mikhail Kirillin; Maria Shakhova; Maria Shakhova; Alina Meller; Alina Meller; Dmitry Sapunov; Pavel Agrba; Pavel Agrba; Alexander Khilov; Mikhail Pasukhin; Olga Kondratieva; Ksenia Chikalova; Tatiana Motovilova; Ekaterina Sergeeva; Ilya Turchin; Natalia Shakhova

doi:10.1117/12.2284671

Medical Laser Applications and Laser-Tissue Interactions VIII
SPIE Proceedings (Optica Publishing Group, 2017),
paper 104170C
•https://doi.org/10.1117/12.2284671

Quantitative Optical Diagnostics in Pathology Recognition and Monitoring of Tissue Reaction to PDT

Mikhail Kirillin, Maria Shakhova, Alina Meller, Dmitry Sapunov, Pavel Agrba, Alexander Khilov, Mikhail Pasukhin, Olga Kondratieva, Ksenia Chikalova, Tatiana Motovilova, Ekaterina Sergeeva, Ilya Turchin, and Natalia Shakhova

European Conference on Biomedical Optics 2017

Munich Germany
25–29 June 2017
ISBN: 9781510612921

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PDT and Vasculatur (PDTV)

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M. Kirillin, M. Shakhova, A. Meller, D. Sapunov, P. Agrba, A. Khilov, M. Pasukhin, O. Kondratieva, K. Chikalova, T. Motovilova, E. Sergeeva, I. Turchin, and N. Shakhova, "Quantitative Optical Diagnostics in Pathology Recognition and Monitoring of Tissue Reaction to PDT," in Medical Laser Applications and Laser-Tissue Interactions VIII, L. Lilge, ed., Vol. 10417 of SPIE Proceedings (Optica Publishing Group, 2017), paper 104170C.

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Abstract

Optical coherence tomography (OCT) is currently actively introduced into clinical practice. Besides diagnostics, it can be efficiently employed for treatment monitoring allowing for timely correction of the treatment procedure. In monitoring of photodynamic therapy (PDT) traditionally employed fluorescence imaging (FI) can benefit from complementary use of OCT. Additional diagnostic efficiency can be derived from numerical processing of optical diagnostics data providing more information compared to visual evaluation. In this paper we report on application of OCT together with numerical processing for clinical diagnostic in gynecology and otolaryngology, for monitoring of PDT in otolaryngology and on OCT and FI applications in clinical and aesthetic dermatology. Image numerical processing and quantification provides increase in diagnostic accuracy.

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