Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Evaluation of a Novel Photosensitizing Drug Having Antitumor Effect for Advanced Prostate Cancer

Not Accessible

Your library or personal account may give you access

Abstract

Prostate cancer is the second most frequently diagnosed cancer among men worldwide and a novel treatment for the disease is required. Replication-deficient virus particles, hemagglutinating virus of Japan envelope (HVJ-E), has cytotoxicity to cancer cells. To enhance the therapeutic effect of HVJ-E by photodynamic therapy (PDT) as a trigger of HVJ-E’s anti-tumor effect, talaporfin sodium (Laserphyrin®) used for PDT was encapsulated into HVJ-E to produce a novel photosensitizing drug, named Laserphyrin®-HVJ-E, and its therapeutic effect for prostate cancer cells (PC-3) was evaluated. As the results, direct cytotoxicities of HVJ-E and Laserphyrin®-HVJ-E for PC-3 after an administration time of 48 h were almost the same. Cell survival rates of PC-3, which were irradiated 2 h after administration of Laserphyrin®-HVJ-E, were about 7.8%. Although further study is needed to find an optimal PDT condition, these results suggest that Laserphyrin®-HVJ-E is useful for treatment of prostate cancer due to the combination of cytotoxicities of HVJ-E and PDT.

© 2017 SPIE

PDF Article
More Like This
Hemagglutinating virus of Japan envelope (HVJ-E) allows targeted and efficient delivery of photosensitizer for photodynamic therapy against advanced prostate cancer

Mizuho Inai, Masaya Yamauchi, Norihiro Honda, Hisanao Hazama, Shoji Tachikawa, Hiroyuki Nakamura, Tomoki Nishida, Hidehiro Yasuda, Yasufumi Kaneda, and Kunio Awazu
OM2D.3 Optical Molecular Probes, Imaging and Drug Delivery (OMP) 2015

Evaluation of the PDT Effect of Foscan® and Fospeg® in the LNCaP Human Prostate Cancer Cell Line

A. Petri, M. Kyriazi, E. Alexandratou, M. Rallis, S. Grafe, and D. Yova
7373_1I European Conference on Biomedical Optics (ECBO) 2009

Enhanced Photodynamic Action with Chlorin e6 and Indocyanine Green Incorporated Mesoporous Silica Nanoparticles against Prostate Cancer Cells

Emel Bakay, Hilal Er, Ayşenur Pamukçu, Didem Şen Karaman, and Nermin Topaloğlu
EW4A.44 European Conference on Biomedical Optics (ECBO) 2021

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved