In vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer

V.V. Klimenko; S.V. Shmakov; N.E. Kaydanov; S.V. Koniakhin; N.A. Knyazev; N.A. Knyazev; N.V. Kazakov; A.A. Rusanov; A.A. Bogdanov; A.A. Bogdanov; M.V. Dubina; M.V. Dubina

doi:10.1117/12.2286457

Medical Laser Applications and Laser-Tissue Interactions VIII
SPIE Proceedings (Optica Publishing Group, 2017),
paper 1041703
•https://doi.org/10.1117/12.2286457

In vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer

V.V. Klimenko, S.V. Shmakov, N.E. Kaydanov, S.V. Koniakhin, N.A. Knyazev, N.V. Kazakov, A.A. Rusanov, A.A. Bogdanov, and M.V. Dubina

European Conference on Biomedical Optics 2017

Munich Germany
25–29 June 2017
ISBN: 9781510612921

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V. V. Klimenko, S. V. Shmakov, N. E. Kaydanov, S. V. Koniakhin, N. A. Knyazev, N. V. Kazakov, A. A. Rusanov, A. A. Bogdanov, and M. V. Dubina, "In vitro singlet oxygen threshold dose at PDT with Radachlorin photosensitizer," in Medical Laser Applications and Laser-Tissue Interactions VIII, L. Lilge, ed., Vol. 10417 of SPIE Proceedings (Optica Publishing Group, 2017), paper 1041703.

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Abstract

In this present study we investigate the Radachlorin photosensitizer accumulation in K562 cells and Hela cells and determined the cell viability after PDT. Using the macroscopic singlet oxygen modeling and cellular photosensitizer concentration the singlet oxygen threshold doses for K562 cells and Hela cells were calculated.

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