Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods

Not Accessible

Your library or personal account may give you access

Abstract

We report on the optoacoustic (OA) imaging of the whole mouse body using a biocompatible contrast agent – highly purified, pegylated gold nanorods (GNR) – which has strong optical absorption in the near-infrared region and low level of toxicity. In vitro toxicity studies showed no significant change in survival rates of the cultured normal epithelium IEC-6 cells when incubated for 24 hours with up to 1 nM of GNR. In vivo toxicity studies in nude mice showed no pathological changes in liver 1 month after the IV injection of GNR with intra-body concentration around 0.25-0.50 nM. In order to study the enhancement of the OA contrast and accumulation of GNR in different tissues, we performed 3D OA imaging of live nude mice with IV-injected GNR. The enhancement of the OA contrast in comparison with the images of the untreated mice was visible starting 1 hour after the GNR injection. The OA contrast of kidneys, liver, and spleen peaked at about 2-3 days after the administration of the GNR, and then was gradually reducing.

© 2011 OSA/SPIE

PDF Article
More Like This
Optoacoustic detection of small volume of tissue and cell clusters targeted with modified gold nanorods

Anton V. Liopo, André Conjusteau, Sergey Ermilov, and Alexander Oraevsky
BSu3A.57 Biomedical Optics (BIOMED) 2012

Switchable Polarization-Sensitive Surface Plasmon Resonance of Highly Stable Gold Nanorods-Liquid Crystals Composites

Qingkun Liu, Jun Qian, Fuhong Cai, Ivan I. Smalyukh, and Sailing He
830810 Asia Communications and Photonics Conference and Exhibition (ACP) 2011

In vivo Photothermal Optical Coherence Tomography of Gold Nanorods in the Mouse Eye

Maryse Lapierre-Landry, Andrew Y. Gordon, John S. Penn, and Melissa C. Skala
BoM3A.2 Bio-Optics: Design and Application (BODA) 2017

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved