Abstract

We demonstrate the feasibility of using a dual-modality fluorescence and x-ray computed tomography (CT) system for quantitative molecular imaging with phantom studies. A CCD based non-contact FT system, which can take measurements from multiple views was built. High-resolution X-Ray CT was used to obtain structural information from the phantom. A 3.6 mm diameter fluorescence inclusion was deeply embedded in the heterogeneous optical background. The results demonstrated that the fluorophore concentration can only be obtained accurately when guided by the a priori information provided by the x-ray CT.

© 2009 OSA/SPIE