Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by Polarization Second Harmonic Microscopy

I. Amat-Roldan; I. Amat-Roldan; S. Psilodimitrakopoulos; E. Eixarch; I. Torre; B. Wotjas; F. Crispi; F. Figueras; D. Artigas; P. Loza-Alvarez; E. Gratacos

doi:10.1364/ECBO.2009.7367_0O

Advanced Microscopy Techniques
Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009),
paper 7367_0O
•https://doi.org/10.1364/ECBO.2009.7367_0O

Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by Polarization Second Harmonic Microscopy

I. Amat-Roldan, S. Psilodimitrakopoulos, E. Eixarch, I. Torre, B. Wotjas, F. Crispi, F. Figueras, D. Artigas, P. Loza-Alvarez, and E. Gratacos

European Conference on Biomedical Optics 2009

Munich Germany
14–18 June 2009
ISBN: 9780819476432

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I. Amat-Roldan, S. Psilodimitrakopoulos, E. Eixarch, I. Torre, B. Wotjas, F. Crispi, F. Figueras, D. Artigas, P. Loza-Alvarez, and E. Gratacos, "Myosin helical pitch angle as a quantitative imaging biomarker for characterization of cardiac programming in fetal growth restriction measured by Polarization Second Harmonic Microscopy," in Advanced Microscopy Techniques, P. Campagnola, E. Stelzer, and G. Von Bally, eds., Vol. 7367 of Proceedings of SPIE-OSA Biomedical Optics (Optica Publishing Group, 2009), paper 7367_0O.

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Abstract

Fetal growth restriction (FGR) has recently shown a strong association with cardiac programming which predisposes to cardiovascular mortality in adulthood. Polarization Second Harmonic Microscopy can quantify molecular architecture changes with high sensitivity in cardiac myofibrils. In this work, we use myosin helical pitch angle as an example to quantify such alterations related to this high risk population. Importantly, this shows a potential use of the technique as an early diagnostic tool and an alternative method to understand pathophysiological processes.

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