Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Wavelengths optimization in multi spectral diffuse optical tomography considering uncertainties in absorption spectra

Not Accessible

Your library or personal account may give you access

Abstract

Using multiple lasers in continuous wave diffuse optical tomography has the advantages that scattering and absorption can be distinguished, and that physiological parameters (chromophore concentrations) can be reconstructed. The choice of the laser wavelengths is crucial to ensure a good separability of scattering and chromophores. Current methods to optimize the wavelengths do not consider the sensitivity of the reconstruction result to deviations of extinction coefficients of the chromophores. But since the available absorption spectra for the individual chromophores show significant deviations, it seems to be necessary to take this into account when optimizing the wavelengths. The wavelength optimization approach presented here is an extension of a method of Corlu et al. An additional criterion is introduced, which evaluates the dependence of reconstructed chromophore concentrations on deviations of the absorption coefficients. The wavelengths found by the new approach are compared to those resulting from the original method. Reconstructions of simulated data show the effect of using various spectra for reconstruction with different wavelength sets and illustrate the advantages of the new wavelength sets, leading to less crosstalk between the chromophore concentrations and lower artifacts.

© 2007 SPIE

PDF Article
More Like This
Optimum wavelengths in continuous-wave multi-spectral diffuse optical tomography

Alper Corlu, Turgut Durduran, Regine Choe, Kijoon Lee, Martin Schweiger, Elizabeth M. C. Hillman, Simon R. Arridge, and Arjun G. Yodh
WB4 Biomedical Topical Meeting (BIOMED) 2004

Optimized Wavelength Selection and Normalization in Spectral Near Infrared Tomography

Hamid Dehghani, Iain B. Styles, Matthew E. Eames, and Brian W. Pogue
BSuD49 Biomedical Optics (BIOMED) 2010

Development of Spectrally-Constrained Diffuse Optical Tomography for Imaging Exogenous Contrast Agents

Scott C. Davis, Brian W. Pogue, Subha Srinivasan, Hamid Dehghani, and Keith D. Paulsen
SH36 Biomedical Topical Meeting (BIOMED) 2006

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved