System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain

Matthias Kohl-Bareis; Roland Gürtler; Ute Lindauer; Christoph Leithner; Heike Sellien; Georg Royl; Ulrich Dirnagl

doi:10.1364/ECBO.2005.WA3

Photon Migration and Diffuse-Light Imaging II
Proc. SPIE (Optica Publishing Group, 2005),
paper WA3
•https://doi.org/10.1364/ECBO.2005.WA3

System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain

Matthias Kohl-Bareis, Roland Gürtler, Ute Lindauer, Christoph Leithner, Heike Sellien, Georg Royl, and Ulrich Dirnagl

European Conference on Biomedical Optics 2005

Munich Germany
12–16 June 2005
ISBN: 0-8194-5861-9

From the session
Functional Optical Imaging of the Brain I (WA)

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M. Kohl-Bareis, R. Gürtler, U. Lindauer, C. Leithner, H. Sellien, G. Royl, and U. Dirnagl, "System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain," in Photon Migration and Diffuse-Light Imaging II, K. Licha and R. Cubeddu, eds., Vol. 5859 of Proc. SPIE (Optica Publishing Group, 2005), paper WA3.

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Abstract

We designed a system incorporating the independent measurement of blood flow and oxygenation of haemoglobin. This is based on laser-Doppler spectroscopy with NIR wavelengths which gives a measure for changes in blood flow or tissue perfusion as well as reflectance spectroscopy in the VIS wavelength range for the calculation of the oxygenated and deoxygenated haemoglobin components. The co-registration of these parameters allows the neurovascular coupling of brain to be investigated. This is demonstrated by recording functional activity of the rat brain during electrical forepaw stimulation.

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