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Conferences > ECBO > 2003 > TFII > 5141_70

Fluorescence Spectroscopy and Imaging for Noninvasive Diagnostics: Applications to Early Cancer Detection in the Lung

Mary-Ann Mycek, Paul Urayama, Wei Zhong, Roger D. Sloboda, Konstantin H. Dragnev, and Ethan Dmitrovsky

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Abstract

Tissue fluorescence spectroscopy and imaging are being investigated as potential methods for non-invasive detection of pre-neoplastic change in the lung and other organ systems. A substantial contribution to tissue fluorescence is known to arise from endogenous cellular fluorophores. Using steady-state and time-resolved fluorescence spectroscopy and imaging, we characterized the endogenous fluorescence properties of immortalized and carcinogen transformed human bronchial epithelial cells. Non-invasive sensing of endogenous molecular biomarkers associated with human bronchial pre-neoplasia will be discussed.

© 2003 SPIE

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