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Optical local and superficial probing of tissues for in vivo diagnosis

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Abstract

An optical tissue diagnosis technique, often called “optical biopsy”, has been developed, It is based on the simultaneous determination of the optical properties of tissues such as the reduced scattering coefficient µs’ and the absorption coefficient µa. These data are obtained by applying a small diameter probe (ø 2mm) on tissues, through the working channel of usual endoscopes. The simultaneous determination of µa and µs’ with a local probe was made possible by the consideration of the first two moments of the phase function and a proven model of light propagation in tissues at propagation length comparable to the scattering mean free path. Non-invasive measurements of the optical coefficients of superficial tissues have been obtained in vivo at different wavelength

© 2003 SPIE

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