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Evaluation of Cerebral Energy Demand during Graded Hypercapnia and Validation of Optical Blood Flow Measurements against ASL fMRI

Stefan A. Carp, Maria Angela Franceschini, David A. Boas, and Young R. Kim

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Abstract

We validate optical cerebral blood flow measurements against functional MRI in a rat model during graded hypercapnia. We test the iso-metabolic assumption and demonstrate an apaprent increase in brain metabolism at higher inhaled CO2 levels.

© 2010 Optical Society of America

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