This work presents endoscopic Doppler optical coherence tomography and autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter fiber catheter. The wide field-of-view of AFI offers rapid and sensitive visual presentation for the detection and localization of possible pulmonary nodules and vascular networks while OCT provides detailed co-registered sub-surface structural information. This dual-modal technique has the potential to enable rapid localization of small pulmonary nodules for biopsy collection, and concurrently, enables the discrimination of nodules from large blood vessels to minimize complications.

© 2016 Optical Society of America

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