Abstract
A Photonic Crystal surface fabricated upon a quartz substrate using nanoimprint lithography has been demonstrated with a signal enhancement factor as high as 7500× for the detection of LD-700 dye spin-coated upon the PC. The detection of spotted Alexa-647 labeled polypeptide on the PC exhibits a 330× SNR improvement. Using dose-response characterization of deposited fluorophore-tagged protein spots, the PCEF surface demonstrated a 140× lower limit of detection compared to a conventional glass substrate.
© 2011 Optical Society of America
PDF ArticleMore Like This
Cheng-Sheng Huang, Sherine George, Meng Lu, Vikram Chaudhery, Ruimin Tan, Richard C. Zangar, and Brian T. Cunningham
AMF5 CLEO: Applications and Technology (CLEO:A&T) 2011
Anusha Pokhriyal, Meng Lu, Vikram Chaudhery, Sherine George, and Brian T. Cunningham
CM4O.3 CLEO: Science and Innovations (CLEO:S&I) 2013
Sherine George, Vikram Chaudhery, Meng Lu, and Brian T. Cunningham
LTh1J.3 Laser Science (LS) 2012