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Optica Publishing Group
  • 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conference
  • (Optica Publishing Group, 2015),
  • paper CL_P_5

Femtosecond versus picosecond pulses for laser-induced transfer of biomaterials

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Abstract

Laser induced forward transfer (LIFT) has been recently modified to transfer living cells or biomolecules. Laser assisted bioprinting (LAB) has emerged as an alternative to ink-jet bioprinting technique due to its resolution [1]. In parallel, needle free (NF) injection systems have been developed to increase vaccination rate and to overcome conventional needles issues like needle stick accidents for instance. Many of the devices in the market use highly compressed gases as the energy sources that lead to the creation of diffuse jet without control of jet shape and a lack of precision. An original LIFT based method has been explored to create thin micro jets inside capillaries with high velocity to penetrate the skin [2]. LAB and NF injection concern different biomaterials but are both based on the creation of bubbles near a free liquid-air interface by laser pulse illumination. Depending on the application, the accurate control of the jet’s characteristics is required in term of maximal height, velocity and diameter. Commercially available laser technologies offer pulse durations ranging from nanosecond to femtosecond to produce micro jet. The benefit of picosecond and femtosecond laser sources compare to nanosecond sources is to induce optical breakdown and the creation of bubbles without absorbing sacrificial layer. Here, we investigate the influence of the pulse duration on the jet creation dynamics. A fiber chirp pulse amplification (FCPA) laser system emitting 400 fs pulses at 1030 nm has been used. Before the interaction with the target, the pulse duration can be continuously tuned from 400 fs to 20 ps by translating the imaging system of a lens-based near to zero-dispersion stretcher unit. A polarizer-based attenuator also controls energy up to 14 µJ. The liquid sample is placed on a 2mm-thick transparent glass plate while the laser beam is focused through the glass plate in the liquid close to the surface by a vertical X20 microscope objective (0,4NA, 10mm focal length) placed on a micrometer translation stage. We used time-resolved Schlieren imaging technics to characterize the jets. Images are recorded for given energies, pulse durations and observation times and all data are then processed by a homemade image processing software extracting jet characteristics (speed, height and full width half maximum) (Fig.1).

© 2015 IEEE

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