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Optica Publishing Group
  • 2017 Conference on Lasers and Electro-Optics Pacific Rim
  • (Optica Publishing Group, 2017),
  • paper s1498

High-throughput, label-free, multivariate cell analysis with optofluidic time-stretch microscopy

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Abstract

We demonstrate a label-free cell analyzer with high throughput and single-cell resolution based on optofluidic time-stretch microscopy. It is capable of acquiring images of cells at a throughput beyond 10,000 cells/s with a spatial resolution of 780 nm in a label-free manner, allowing for statistical analysis of the cells’ phenotypes from the images via machine learning methods. Moreover, using compressed sensing, the throughput can be further improved by a factor of 50. Thus, our scheme holds great potential for cell analysis in various scientific and industrial fields, including bio-fuel production and disease evaluation.

© 2017 Optical Society of America

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