Abstract
A noninvasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies, based on the volume elastic scattering properties of the tissue, over a. wide range of wavelengths. The use of elastic scattering for optical tissue diagnostics derives from the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and subcellular level, which can be expected to cause significant changes in an optical signature that is derived from spectral measurements of the wavelength-dependence of elastic scattering.
© 1994 Optical Society of America
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