Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Contrast enhancement in tumor localization using hematoporphyrin derivative laser-induced fluorescence

Not Accessible

Your library or personal account may give you access

Abstract

In tumor localization based on the tumor-seeking properties of hematoporphyrin derivative (HpD),1 induced red fluorescence at wavelengths λ > 600 nm is normally observed. However, there is frequently a background red fluorescence even in the absence of HpD injection. A much improved contrast between tumor tissue and normal tissue can be achieved if simple functions of fluorescence intensities of different wavelengths are monitored.2 We have performed a model experiment on rats with induced leg tumors employing N2 laser excitation and optical multichannel detection. Tissue from 15 different organs were investigated for rats that had received a 5-mg/kg body weight injection 1–4 days prior to the measurements. In Fig. 1 spectra of tumor tissue from HpD-injected and control rats are shown as well as a spectrum for muscle at the tumor position but on the unaffected leg.

© 1984 Optical Society of America

PDF Article
More Like This
Contrast Enhancement in Tumor Localization Using Hematoporphyrin-Derivative Laser-Induced Fluorescence

J. Ankerst, S. Montan, K. Svanberg, and S. Svanberg
FG3 International Quantum Electronics Conference (IQEC) 1984

Multicolor imaging and contrast enhancement in cancer tumor localization using laser- induced fluorescence in hematoporphyrin derivative-bearing tissue

S. MONTAN, S. SVANBERG, and K. SVANBERG
WF2 Conference on Lasers and Electro-Optics (CLEO:S&I) 1985

Treatment of Intraocular Tumors with Hematoporphyrin-Derivative Photoradiation Therapy

Charles J. Gomer, A. Linn Murphree, Daniel R. Doiron, Nicholas J. Razum, and Stanley W. Fountain
FG2 International Quantum Electronics Conference (IQEC) 1984

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved