Abstract
In tumor localization based on the tumor-seeking properties of hematoporphyrin derivative (HpD),1 induced red fluorescence at wavelengths λ > 600 nm is normally observed. However, there is frequently a background red fluorescence even in the absence of HpD injection. A much improved contrast between tumor tissue and normal tissue can be achieved if simple functions of fluorescence intensities of different wavelengths are monitored.2 We have performed a model experiment on rats with induced leg tumors employing N2 laser excitation and optical multichannel detection. Tissue from 15 different organs were investigated for rats that had received a 5-mg/kg body weight injection 1–4 days prior to the measurements. In Fig. 1 spectra of tumor tissue from HpD-injected and control rats are shown as well as a spectrum for muscle at the tumor position but on the unaffected leg.
© 1984 Optical Society of America
PDF ArticleMore Like This
J. Ankerst, S. Montan, K. Svanberg, and S. Svanberg
FG3 International Quantum Electronics Conference (IQEC) 1984
S. MONTAN, S. SVANBERG, and K. SVANBERG
WF2 Conference on Lasers and Electro-Optics (CLEO:S&I) 1985
Charles J. Gomer, A. Linn Murphree, Daniel R. Doiron, Nicholas J. Razum, and Stanley W. Fountain
FG2 International Quantum Electronics Conference (IQEC) 1984