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Two-Photon Imaging Reveals Capillary Occlusions are Responsible for Reduced Brain Blood Flow and Cognitive Decline in Alzheimer’s Disease Mouse Models

Jean C. Cruz Hernández, Oliver Bracko, Calvin Kersbergen, Victorine Muse, Mohammad Haft-Javaherian, Iryna Ivasyk, Laibaik Park, Lindsay Vinarcsik, Yiming Kang, Joan Zhou, Jeffrey D. Beverly, Elizabeth Slack, Gabriel Otte, Thom P. Santisakultarm, Costantino Iadecola, Nozomi Nishimura, and Chris B. Schaffer

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Abstract

Using in vivo nonlinear microscopy, we found 2% of brain capillaries were occluded by an adhered leukocyte in Alzheimer’s disease mice. Blocking this adhesion eliminated these stalls, improved brain blood flow by 30%, and restored spatial memory.

© 2017 Optical Society of America

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