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An imaging system was used to monitor the fluorescence of disulphonated Aluminum Phthalocyanine during the PDT of tumors to check whether an index for therapy effectiveness could be found out. Two excitation wavelengths were tested to discover a possible change in the absorption spectrum of the sensitizer induced by the treatment. Two opposite phenomena take place in the tumor area: a mild photobleaching in the region directly irradiated and a marked increase in the fluorescence signal at the tumor borders. The different behavior observed with the two excitation wavelengths demonstrates that the drug absorption spectrum shifts towards shorter wavelengths as a result of the irradiation.
© 2000 Optical Society of America
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