Abstract

A optical fiber, needle-based, ratiometer for breast tumor targeting has been developed as an optical biopsy technique based on fluorescence spectroscopy. In vitro breast cancerous and normal tissues were measured using the ratiometer. Simulated experiments of detecting tumor in a breast were performed using a "sandwich" model made up of three tissue layers. Fluorescence measurement from these samples would be consistent with detection of cancerous tissue surrounded by normal breast tissue.

© 1998 Optical Society of America