Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Supercontinuum Parallel Line-Field Optical Coherence Tomography for High Sensitivity, Kilohertz Frame Rate Imaging

Open Access Open Access

Abstract

Emerging supercontinuum (SC) light sources suitable for optical coherence tomography (OCT) offer greater illumination power than conventional sources, and large optical bandwidths for ultrahigh-resolution imaging. Because there is a tradeoff between power and sensitivity, by distributing the power across a line for sample illumination, we can avoid perturbing cellular behavior while increasing imaging sensitivity. Here we demonstrate an SC-based, spectral-domain, parallel line-field OCT system, and show that it exhibits an unprecedented combination of resolution, speed, and sensitivity for capturing cellular dynamics. We employ the system for imaging of human bronchial epithelial cells in vitro which exhibit rapid ciliary motion that is highly spatially localized.

© 2017 Optical Society of America

PDF Article
More Like This
Ultrahigh resolution optical coherence tomography using supercontinuum and their wavelength dependence

Norihiko Nishizawa, Hiroyuki Kawagoe, and Masahito Yamanaka
AF2A.2 CLEO: Applications and Technology (CLEO:A&T) 2017

High-Sensitivity Contrast-Enhanced in vivo Imaging with Optical Coherence Tomography (OCT)

Orly Liba, Elliott D. SoRelle, Debasish Sen, and Adam de la Zerda
AW4A.3 CLEO: Applications and Technology (CLEO:A&T) 2017

Fourier synthesis of optical diffraction tomography patterns for kilohertz frame rate volumetric imaging

Peter T. Brown and Douglas P. Shepherd
NTu1C.4 Novel Techniques in Microscopy (NTM) 2023

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved