Flat-mounted and sliced retinas were used for concurrent optical imaging and electrophysiological recording of stimulus-evoked neural activities. High spatiotemporal resolution imaging revealed fast intrinsic optical signals (IOSs) that had time courses comparable to electrophysiological kinetics. IOS imaging allowed simultaneous monitoring of dynamic neural activities from the photoreceptor to inner retinal neurons.

© 2011 Optical Society of America

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