Abstract

We demonstrate the use of phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to visualize and quantify the low-amplitude elastic wave propagation in tissue with ultra-high frame rate. PhS-SSOCE is based on 1-D transverse scanning of the M-mode OCT imaging that is precisely synchronized with a low-pressure short-duration air-puff loading system. This approach of scanning and data recording allows visualizing the induced tissue deformation at high frame rate. The results indicate that phantoms with higher concentration of gelatin as well as older mouse corneas have higher shear wave speeds that can be related to stiffer material. This non-contact and noninvasive measurement technique utilizes minimal force/amplitude for excitation (in µm scale) of the tissue that can be potentially used to study the biomechanical properties of ocular and other tissues.

© 2014 Optical Society of America