Underpinning the microvascular origin of BOLD-fMRI with two-photon microscopy

Louis Gagnon; Louis Gagnon; Louis Gagnon; Sava Sakadžić; Frédéric Lesage; Joseph J. Musacchia; Joël Lefebvre; Qianqian Fang; Meryem A. Yücel; Karleyton C. Evans; Emiri T. Mandeville; Julien Cohen-Adad; Jonathan R. Polimeni; Mohammad A. Yaseen; Eng H. Lo; Douglas N. Greve; Richard B. Buxton; Anders M. Dale; Anna Devor; Anna Devor; David A. Boas; David A. Boas

doi:10.1364/BIOMED.2014.BT4A.1

Biomedical Optics 2014
OSA Technical Digest (online) (Optica Publishing Group, 2014),
paper BT4A.1
•https://doi.org/10.1364/BIOMED.2014.BT4A.1

Underpinning the microvascular origin of BOLD-fMRI with two-photon microscopy

Louis Gagnon, Sava Sakadžić, Frédéric Lesage, Joseph J. Musacchia, Joël Lefebvre, Qianqian Fang, Meryem A. Yücel, Karleyton C. Evans, Emiri T. Mandeville, Julien Cohen-Adad, Jonathan R. Polimeni, Mohammad A. Yaseen, Eng H. Lo, Douglas N. Greve, Richard B. Buxton, Anders M. Dale, Anna Devor, and David A. Boas

Biomedical Optics 2014

Miami, Florida United States
26–30 April 2014
ISBN: 978-1-55752-997-8

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Multiphoton Nonlinear Microscopy (BT4A)

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L. Gagnon, S. Sakadžić, F. Lesage, J. J. Musacchia, J. Lefebvre, Q. Fang, M. A. Yücel, K. C. Evans, E. T. Mandeville, J. Cohen-Adad, J. R. Polimeni, M. A. Yaseen, E. H. Lo, D. N. Greve, R. B. Buxton, A. M. Dale, A. Devor, and D. A. Boas, "Underpinning the microvascular origin of BOLD-fMRI with two-photon microscopy," in Biomedical Optics 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper BT4A.1.

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Abstract

We have developed a model of BOLD-fMRI from first principles using from two-photon microscopic measurements of cerebrovascular physiology. The model was validated against experimental BOLD measurements at several levels. Our bottom up approach predicted a new phenomenon: the folding of the cortical surface produces variations in BOLD signal corresponding to 40% of the amplitude of the BOLD signal generated by neuronal activation. This prediction was further validated experimentally with human BOLD-fMRI measurements, confirming the predictive power of our approach.

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