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In Vivo Fluorescence Lifetime Detection of a Cathepsin-Activatable Probe in Infarcted Myocardium

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Abstract

Using a protease-activatable near-infrared probe, we demonstrate that lifetime-based time domain imaging can improve fluorescence contrast useful for detecting myocardial infarctions in vivo and for isolating the non-specific signal from the liver.

© 2012 Optical Society of America

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