A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum: Results from Studies in Dynamic Phantoms

Ilias Tachtsidis; Terence S. Leung; Bilal Tahir; Clare E. Elwell; Matthias Kohl-Bareis; Markus Gramer; Chris E. Cooper

doi:10.1364/BIOMED.2008.BSuE76

Biomedical Optics
OSA Technical Digest (CD) (Optica Publishing Group, 2008),
paper BSuE76
•https://doi.org/10.1364/BIOMED.2008.BSuE76

A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum: Results from Studies in Dynamic Phantoms

Ilias Tachtsidis, Terence S. Leung, Bilal Tahir, Clare E. Elwell, Matthias Kohl-Bareis, Markus Gramer, and Chris E. Cooper

Biomedical Optics 2008

St. Petersburg, Florida United States
16–19 March 2008
ISBN:

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BIOMED Poster Session I (BSuE)

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I. Tachtsidis, T. S. Leung, B. Tahir, C. E. Elwell, M. Kohl-Bareis, M. Gramer, and C. E. Cooper, "A Hybrid Multi-Distance Phase and Broadband Spatially Resolved Algorithm for Resolving Absolute Concentrations of Chromophores in the Near-Infrared Light Spectrum: Results from Studies in Dynamic Phantoms," in Biomedical Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2008), paper BSuE76.

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Abstract

For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. We report a novel methodology that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a spatially resolved algorithm. Preliminary results in a dynamic phantom showed good agreement between measured and theoretical calculated absolute concentrations of known dyes.

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