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Sensitivity Analysis for Frequency-Domain Optical Tomography of Small Tissue Volumes

Xuejun Gu, Uwe J. Netz, Kui Ren, Jürgen Beuthan, and Andreas H. Hielscher

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Abstract

We perform numerical and experimental sensitivity analyses for the imaging problem in small-volume optical tomography with the frequency-domain equation of radiative transfer as light propagation model. Varying the optical properties, tissue geometries, and contrast, we show that source modulation frequencies in the range of 300-600MHz yield maximal signal-to-noise ratios and therefore maximal sensitivity to tissue inhomogeneities.

© 2006 Optical Society of America

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