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Differential heterodyne Mach-Zehnder interferometer for measurement of nanometer-scale motions in living cells

Christopher Fang-Yen, Seungeun Oh, Sen Song, H. Sebastian Seung, Ramachandra R. Dasari, and Michael S. Feld

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Abstract

We have developed a novel differential heterodyne Mach-Zehnder interferometer for measuring sub-nanometer displacements in single cells. We describe efforts to measure voltage-dependent refractive index changes and mechanical fluctuations in cultured single neurons.

© 2006 Optical Society of America

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