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Imaging of targeted fluorescence signal for tumor detection using dual-interfering-source excitation

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Abstract

Fluorescent field re-radiated from an object embedded in a highly scattering medium illuminated by dual-interfering-source possesses some unique features, i.e., amplitude null and 180° phase transition when the object is crossing the mid-plane between those two sources. This allows us to accurately localize the fluorescent object inside the turbid media. Using this method, we can image the location of an 8 mm mouse tumor labeled with fluorescent dye embedded 3 cm deep in the scattering media.

© 2002 Optical Society of America

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