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Correlation between total hemoglobin concentration and blood volume of breast tumors measured by NIR spectroscopy and 19F MRS of PFOB

Yulin Song, Yueqing Gu, Jae G. Kim, Hanli Liu, Anca Constantinescu, and Ralph P. Mason

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Abstract

Correlation between total hemoglobin concentration and blood volume in solid mammary tumors was explored using both NIRS and 19F MRS of PFOB, respectively, while studying dynamic changes in tumor vascular volume induced by a vasoactive agent, carbogen. A close correlation between the results obtained from the two methods indicates the potential utility of NIRS for noninvasive in vivo quantification of tumor blood volume.

© 2002 Optical Society of America

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