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Conferences > BIO > 1999 > BWB > BWB1

Investigation of telomeric DNA structures by a covalently linked BODIPY dye

Ta-Chau Chang, Ching-Tung Kuo, Chien-Chih Chiang, and Cheng-Sheng Yan

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Abstract

Here we illustrate that nonresonant hole (NRH) spectroscopic method can be used to investigate the interactions and structures of various guanine-rich (G-rich) oligonucleotides that have made covalently linked by a dye of 4,4-difluoro-5-(4-phenyl- l,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-propionic acid, succinimidyl ester (BODIPY) at the 5’ end. Telomeres, the ends of chromosomes, are essential for the stability and replication of eukaryotic chromosomes [1].

© 1999 Optical Society of America

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