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Optofluidic Cytometer for Characterization of Circulating Tumore Cell

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Abstract

In this paper, we demonstrate a low cost and compact optofluidic cytometer which is able to characterize the biological cells by analyzing multiple phenotypical and biochemical parameters. This device includes the microfluidic focusing and optical detection components on a glass substrate with PDMS. Multiple parameters such as fluorescence, side scatter, and forward scatter are obtained to provide 3-dimensional plots for the determination of cell types and subpopulations. As a specific biomedical application, the proposed compact opfluidic cytometer is able to provide a rapid and low cost platform for detection of tumor cells.

© 2013 Optical Society of America

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